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Article

Association between end-stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms.

Nephrology (Carlton, Vic.) - 1 Feb 2019

Ramanathan Gnanasambandan, Harichandana Bollimpalli, Kannan Suresh, Elumalai Ramprasad, Sfd Paul

Abstract excerpt

AIM: Methylenetetrahydrofolate reductase (MTHFR) is a regulatory enzyme of homocysteine metabolism. The C677T and A1298C polymorphism of the MTHFR gene has been reported to be associated with elevated plasma homocysteine in patients with Diabetic nephropathy. This study aimed to investigate the influence of the C677T and A1298C polymorphisms on the progression chronic kidney disease in diabetic nephropathy of...

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Source

Identifiers

PMID: 29227003
DOI: 10.1111/nep.13208

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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