Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.

doi:10.1016/j.diabres.2003.10.022

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Article

Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.

Diabetes research and clinical practice - 1 Jun 2004

Sun Jiazhong, Xu Yancheng, Zhu Yilian, Lu Hongyun

Abstract excerpt

OBJECTIVE: Genetic predisposition has been implicated in diabetic nephropathy (DN). The C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene, one of the key enzymes catalyzing remethylation of homocysteine, may play a role in the development of not only vascular disease but also diabetic microangiopathies. In this study, we examined the distribution of the MTHFR genotypes in the Chinese...

Topics

Asian People
Chromatography, High Pressure Liquid
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Female
Genotype
Homocysteine
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
Spectrometry, Fluorescence

Source

Open in PubMed

Identifiers

PMID: 15126006
DOI: 10.1016/j.diabres.2003.10.022

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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