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Article

Overexpression of Rtl1 via synonymous mutation silencing miRNA target site drives skeletal muscle hypertrophy and inflammation in mice.

BMC biology - 6 Feb 2026

Song Xianwei, Niu Lizhu, Fan Xiaoxuan, Xu Xianghua, Zhao Zihao, Zhang Zhixuan, Tong Yingwei, Huang Hao, Zhu Zhengmao, Cheng Huijun, Xie Shengsong, Xu Xuewen

Abstract excerpt

BACKGROUND: The retrovirus-derived Rtl1 gene is integral to skeletal muscle development. However, the underlying mechanisms and functional roles of Rtl1 in skeletal muscle growth remain unclear. RESULTS: We generated conditional overexpression of Rtl1 in mice via synonymous mutations that silence seven miRNA target sites, thereby efficiently abolishing miRNA-mediated inhibition in vivo. This conditional, specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41645234
DOI: 10.1186/s12915-026-02534-6
PMCID: PMC12973596

Genes

STAT3
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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