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Article

Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy.

Scientific reports - 9 Feb 2018

Zou Yunlong, Dong Yanjun, Meng Qingyong, Zhao Yaofeng, Li Ning

Abstract excerpt

In this study, we upregulated insulin-like growth factor-1 (IGF1) expression specifically in skeletal muscle by engineering an enhancer into its non-coding regions and verified the expected phenotype in a mouse model. To select an appropriate site for introducing a skeletal muscle-specific myosin light chain (MLC) enhancer, three candidate sites that exhibited the least evolutionary conservation were chosen and...

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Share to Animals, Genetically Modified
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertrophy

Share to Insulin-Like Growth Factor I

Share to Muscle Fibers, Skeletal

Share to Muscular Diseases

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Source

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Identifiers

PMID: 29426944
DOI: 10.1038/s41598-018-21122-5
PMCID: PMC5807547

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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