Article
Rapid intra-host diversification and evolution of SARS-CoV-2 in advanced HIV infection.
Nature communications - 22 Aug 2024
Ko Sung Hee, Radecki Pierce, Belinky Frida, Bhiman Jinal N, Meiring Susan, Kleynhans Jackie, Amoako Daniel, Guerra Canedo Vanessa, Lucas Margaret, Kekana Dikeledi, Martinson Neil, Lebina Limakatso, Everatt Josie, Tempia Stefano, Bylund Tatsiana, Rawi Reda, Kwong Peter D, Wolter Nicole, von Gottberg Anne, Cohen Cheryl, Boritz Eli A
Abstract excerpt
Previous studies have linked the evolution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic variants to persistent infections in people with immunocompromising conditions, but the processes responsible for these observations are incompletely understood. Here we use high-throughput, single-genome amplification and sequencing (HT-SGS) to sequence SARS-CoV-2 spike genes from people with HIV...
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