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Article

Bicuculline reversal of aminoglycoside O-nucleotidyltransferase EanT-1-mediated kanamycin resistance.

BMC microbiology - 3 Feb 2026

Wang Jiahui, Yu Minghui, Zhang Mingzhen, Meng Zhihui, Yang Peitong, Cui Xingyu, Yu Ziqian, Wang Yongan, Zong Gongli

Abstract excerpt

BACKGROUND: Kanamycin, an aminoglycoside, is an effective broad-spectrum antimicrobial agent against bacterial infections. However, the clinical efficacy of aminoglycosides has been overshadowed by the emergence of resistance mechanisms involving enzyme-mediated covalent modifications. Aminoglycoside nucleotidyltransferases (ANTs) inactivate aminoglycosides via AMP group transfer. Elucidating their molecular...

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Identifiers

PMID: 41634562
DOI: 10.1186/s12866-026-04746-w
PMCID: PMC12990473

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