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In vitroactivity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae andAcinetobacter baumannii

6 Dec 2018

Abstract excerpt

OBJECTIVES: Widespread antimicrobial resistance often limits the availability of therapeutic options to only a few last-resort drugs that are themselves challenged by emerging resistance and adverse side effects. Apramycin, an aminoglycoside antibiotic, has a unique chemical structure that evades almost all resistance mechanisms including the RNA methyltransferases frequently encountered in...

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PMID: 30629184
DOI: 10.1093/jac/dky546

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