Article
Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone-Neomycin Conjugates.
ACS infectious diseases - 10 Mar 2017
Degtyareva Natalya N, Gong Changjun, Story Sandra, Levinson Nathanael S, Oyelere Adegboyega K, Green Keith D, Garneau-Tsodikova Sylvie, Arya Dev P
Abstract excerpt
The antibacterial effects of aminoglycosides are based on their association with the A-site of bacterial rRNA and interference with the translational process in the bacterial cell, causing cell death. The clinical use of aminoglycosides is complicated by resistance and side effects, some of which arise from their interactions with the human mitochondrial 12S rRNA and its deafness-associated mutations, C1494U and...
Topics
- Aminoglycosides
- Anthraquinones
- Anti-Infective Agents
- Binding Sites
- Drug Resistance, Microbial
- Humans
- Microbial Sensitivity Tests
- Mutation
- Neomycin
- RNA, Bacterial
- RNA, Ribosomal