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The antihelminth drug rafoxanide reverses chromosomal-mediated colistin-resistance in Klebsiella pneumoniae

25 Sept 2023

Abstract excerpt

ABSTRACT The emergence and rapid spread of multi-drug-resistant (MDR) bacteria pose a serious threat to global healthcare. Although the synergistic effect of rafoxanide and colistin was reported, little is known regarding the potential mechanism of this synergy, particularly against chromosomal-mediated colistin-resistant Klebsiella pneumoniae . In the present study, we elucidated the synergistic effect of...

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PMID: 37747188
DOI: 10.1128/msphere.00234-23

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