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Article

Happening in the Prostate Tumor Microenvironment: Ion Channels and Extrachromosomal DNA Driving Phenotypic Plasticity.

The Prostate - 1 May 2026

Darbandi Sara, Urbanucci Alfonso, Hakkola Sini, Gujral Juanita, Darbandi Mahsa, Eraky Ahmed, Nair Sujit, Chakraborty Goutam, Tewari Ashutosh, Kyprianou Natasha

Abstract excerpt

BACKGROUND: Plasticity of cancer, including epithelial-mesenchymal transition (EMT), cancer stem cell (CSC) self-renewal, and microenvironmental adaptation, drives metastasis, therapy resistance, and poor outcomes in prostate cancer (PCa). Ion channels and extrachromosomal DNA (ecDNA) have emerged as key drivers of such adaptive processes by influencing signaling, metabolism, and immune interactions. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41632930
DOI: 10.1002/pros.70139

Genes

CACNA1H
CLIC1
EGFR
KCNJ10
MYC
SLC25A1
SLC25A10
SLC25A33
SLC25A42
SLC29A2
SLC7A11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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