Article
Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.
Cell - 26 Jul 2018
Quigley David A, Dang Ha X, Zhao Shuang G, Lloyd Paul, Aggarwal Rahul, Alumkal Joshi J, Foye Adam, Kothari Vishal, Perry Marc D, Bailey Adina M, Playdle Denise, Barnard Travis J, Zhang Li, Zhang Jin, Youngren Jack F, Cieslik Marcin P, Parolia Abhijit, Beer Tomasz M, Thomas George, Chi Kim N, Gleave Martin, Lack Nathan A, Zoubeidi Amina, Reiter Robert E, Rettig Matthew B, Witte Owen, Ryan Charles J, Fong Lawrence, Kim Won, Friedlander Terence, Chou Jonathan, Li Haolong, Das Rajdeep, Li Hui, Moussavi-Baygi Ruhollah, Goodarzi Hani, Gilbert Luke A, Lara Primo N, Evans Christopher P, Goldstein Theodore C, Stuart Joshua M, Tomlins Scott A, Spratt Daniel E, Cheetham R Keira, Cheng Donavan T, Farh Kyle, Gehring Julian S, Hakenberg Jörg, Liao Arnold, Febbo Philip G, Shon John, Sickler Brad, Batzoglou Serafim, Knudsen Karen E, He Housheng H, Huang Jiaoti, Wyatt Alexander W, Dehm Scott M, Ashworth Alan, Chinnaiyan Arul M, Maher Christopher A, Small Eric J, Feng Felix Y
Abstract excerpt
While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we identified structural variants altering critical regulators of tumorigenesis and progression not...
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