Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer.

doi:10.1158/0008-5472.CAN-24-5018

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Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer.

Cancer research - 1 Oct 2025

Ma Sheng, Ge Yue, Lu Zequn, Zhang Junbiao, Zhang Qin, Peng Yuzheng, Xi Zirui, Peng Hao, Xu Meng-Yao, Xiong Zezhong, Gao Yuan, Wang Yanan, Li Le, Zhang Chunyu, Chao Zheng, Li Tengfei, Zhang Ruiyun, Zhang Qiang, Horne David A, Wang Baojun, Gao Xu, Zhang Xu, Tian Jianbo, Li Jing, Jin Meng, Wei Gong-Hong, Wang Zhihua

Abstract excerpt

Prostate cancer is the most prevalent cancer among men worldwide and exhibits significant genetic heritability. In this study, we performed an integrative analysis combining chromatin accessibility profiling, transcriptomics, and two-stage case-control studies, alongside an unbiased phenome-wide exploration in the FinnGen cohort. This comprehensive approach identified the enhancer-associated SNP rs7077830 at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40758996
DOI: 10.1158/0008-5472.CAN-24-5018
PMCID: PMC12485374

Genes

NCOA4
ZNF384

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