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Article

Genetic polymorphisms of tumor necrosis factor receptor-associated factor 3 and their association with acute lymphoblastic leukemia.

Cancer genetics - 1 Apr 2026

Alkhulaifi Fadwa M, Hakami Hana, Alshammari Jamilah, Alqarzae Safa A, Almuhaini Aeshah, Aloyouni Sheka Y, Alomar Suliman

Abstract excerpt

BACKGROUND: Acute lymphoblastic leukemia (ALL) is an aggressive hematological malignancy driven by genetic and immunological dysregulation. Tumor necrosis factor receptor-associated factor 3 (TRAF3) plays an essential role in regulating immune signaling, lymphocyte homeostasis, and NF-κB pathways. Although TRAF3 alterations have been implicated in various immune disorders and hematologic cancers, the contribution...

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Identifiers

PMID: 41619431
DOI: 10.1016/j.cancergen.2026.01.012

Genes

TRAF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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