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Article

A genome-structure adaptive framework for ROH-based inbreeding estimation in Penaeus vannamei.

Scientific reports - 30 Jan 2026

Zou Xiang, Zhou Hao, Liu Mianyu, Qiang Guangfeng, Dai Ping, Sui Juan, Kong Jie, Luo Kun, Meng Xianhong, Xing Qun, Fu Qiang, Luan Sheng

Abstract excerpt

Reliable genomic inbreeding estimation in aquaculture species is challenged by genome fragmentation, high heterozygosity and unoptimized parameters. This study developed a genome-structure adaptive framework for optimizing Runs of Homozygosity (ROH) detection parameters, using Penaeus vannamei as a model. Taking advantage of whole-genome resequencing of five inbred families and two reference genomes with distinct...

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PMID: 41617790
DOI: 10.1038/s41598-026-37622-8
PMCID: PMC12913633

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