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Article

Genome-wide scan for runs of homozygosity identifies potential candidate genes associated with local adaptation in Valle del Belice sheep.

Genetics, selection, evolution : GSE - 14 Nov 2017

Mastrangelo Salvatore, Tolone Marco, Sardina Maria T, Sottile Gianluca, Sutera Anna M, Di Gerlando Rosalia, Portolano Baldassare

Abstract excerpt

BACKGROUND: Because very large numbers of single nucleotide polymorphisms (SNPs) are now available throughout the genome, they are particularly suitable for the detection of genomic regions where a reduction in heterozygosity has occurred and they offer new opportunities to improve the accuracy of inbreeding ([Formula: see text]) estimates. Runs of homozygosity (ROH) are contiguous lengths of homozygous segments...

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Identifiers

PMID: 29137622
DOI: 10.1186/s12711-017-0360-z
PMCID: PMC5684758

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