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Article

Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence.

Molecular bioSystems - 25 Jul 2017

Hassan Mubashir, Abbas Qamar, Raza Hussain, Moustafa Ahmed A, Seo Sung-Yum

Abstract excerpt

Misfolding and structural alteration in proteins lead to serious malfunctions and cause various diseases in humans. Mutations at the active binding site in tyrosinase impair structural stability and cause lethal albinism by abolishing copper binding. To evaluate the histidine mutational effect, all mutated structures were built using homology modelling. The protein sequence was retrieved from the UniProt...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28640309
DOI: 10.1039/c7mb00211d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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