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Article

Neoadjuvant therapy-associated malignant phenotype score predicts prognosis and highlights the roles of MIF signaling and DUXAP8 in ESCC.

Frontiers in immunology - 1 Jan 2025

Xia Wenchao, Lin Tan, Shi Mengnan, Mu Qiuqiao, Zhang Han, Xu Yijun

Abstract excerpt

Background: Esophageal squamous cell carcinoma (ESCC) remains a major malignancy globally, and long-term survival outcomes remain poor despite advances in multimodal treatment strategies. Neoadjuvant therapy (NAT) has become the standard of care for resectable ESCC; however, substantial interpatient heterogeneity in treatment response persists. Defining malignant cell-intrinsic molecular determinants linked to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41613113
DOI: 10.3389/fimmu.2025.1683349
PMCID: PMC12847432

Genes

MIF
ACKR3
CD44
CD74
CXCR4

Provenance

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