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Transcriptomics based multi-dimensional characterization and drug screen in esophageal squamous cell carcinoma

1 Aug 2021

Abstract excerpt

Background Esophageal squamous cell carcinoma (ESCC) remains one of the deadly cancer types. Comprehensively dissecting the molecular characterization and the heterogeneity of ESCC paves the way for developing more promising therapeutics. Methods Expression profiles of multiple ESCC datasets were integrated. ATAC-seq and RNA-seq were combined to reveal the chromatin accessibility features. A prognosis-related...

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PMID: 34365093
DOI: 10.1016/j.ebiom.2021.103510

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