Article
A migration/invasion-related prognostic signature identifies and functionally validates SLC25A5 as a hub associated with spliceosome programs and invasive phenotypes in esophageal squamous cell carcinoma.
Functional & integrative genomics - 13 Jun 2026
Guo Jinzhou, Si Gao, Si Fuchun
Abstract excerpt
Background esophageal squamous cell carcinoma (ESCC) is highly aggressive and associated with poor survival outcomes. Whether migration/invasion-related transcriptional programs are coupled to RNA splicing regulation and distinct tumor immune microenvironment (TME) features, and how these relationships inform prognosis, remain incompletely understood. Methods using TCGA-ESCC RNA-seq data, we developed a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.