Article
VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett's esophagus.
Nature communications - 29 Jan 2026
Ravillah Durgadevi, Singh Salendra, Katabathula Ramachandra M, Kresak Adam M, Udhayakumar Bhavatharini, Gupta Rajesh, Brock Wendy, Mitani Yosuke, Jain Vaibhav, Hocke Emily, Gregory Simon G, Garman Katherine S, Gabre Joel T, Fujioka Hisashi, Willis Joseph E, Chak Amitabh, Guda Kishore
Abstract excerpt
The molecular underpinnings contributing to the onset of Barrett's esophagus (BE) remain elusive. By studying familial clusters of the disease, here we identify a significant association between genetic variants in the V-set and Immunoglobulin Domain Containing 10 Like (VSIG10L) gene and BE predisposition. Using mammalian tissues and patient-derived organoids, we show VSIG10L is selectively expressed in the...
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