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Article

Pathophysiology of Eosinophilic Esophagitis.

Gastroenterology - 1 Jan 2018

O'Shea Kelly M, Aceves Seema S, Dellon Evan S, Gupta Sandeep K, Spergel Jonathan M, Furuta Glenn T, Rothenberg Marc E

Abstract excerpt

Eosinophilic esophagitis is an emerging disease that is distinguished from gastroesophageal reflux disease by the expression of a unique esophageal transcriptome and the interplay of early life environmental factors with distinct genetic susceptibility elements at 5q22 (TSLP) and 2p23 (CAPN14). Rare genetic syndromes have uncovered the contribution of barrier disruption, mediated in part by defective desmosomes...

Topics

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Allergens
Ehlers-Danlos Syndrome
Eosinophils
Esophagus
Food Hypersensitivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastroesophageal Reflux

Loeys-Dietz Syndrome

Proton Pump Inhibitors

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Open in PubMed Open full text

Identifiers

PMID: 28757265
DOI: 10.1053/j.gastro.2017.06.065
PMCID: PMC5787048

Genes

CAPN14
TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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