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Article

Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.

Journal of virology - 1 Apr 2012

Ambrose Zandrea, Lee KyeongEun, Ndjomou Jean, Xu Hongzhan, Oztop Ilker, Matous James, Takemura Taichiro, Unutmaz Derya, Engelman Alan, Hughes Stephen H, KewalRamani Vineet N

Abstract excerpt

The antiviral factor CPSF6-358 interferes with the nuclear entry of human immunodeficiency virus type 1 (HIV-1). HIV-1 acquires resistance to CPSF6-358 through the N74D mutation of the capsid (CA), which alters its nuclear entry pathway. Here we show that compared to wild-type (WT) HIV-1, N74D HI...

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Share to Active Transport, Cell Nucleus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclophilin A

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Share to Reverse Transcriptase Inhibitors

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Source

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Identifiers

PMID: 22301145
DOI: 10.1128/JVI.05887-11
PMCID: PMC3318671

Genes

CPSF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22301145-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.PMID 22301145Read ↗

HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear EntrySemantic proximity Read ↗

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integrationSemantic proximity Read ↗

Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages.Semantic proximity Read ↗

TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection.Semantic proximity Read ↗

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A Carboxy-Terminally Truncated Human CPSF6 Lacking Residues Encoded by Exon 6 Inhibits HIV-1 cDNA Synthesis and Promotes Capsid DisassemblySemantic proximity Read ↗

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