Field-effect-informed urine liquid biopsy for bladder cancer.

doi:10.1016/j.cell.2025.12.054

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Field-effect-informed urine liquid biopsy for bladder cancer.

Cell - 19 Feb 2026

Shi William Y, Liu Kevin J, Esfahani Mohammad S, Mach Kathleen E, Phillips Nick A, Almanza Diego, Bajpai Ravi K, Schroers-Martin Joseph G, Trabanino Ludimila, Lee Timothy J, La Vinh, Rodriguez Gabriela, Holton Grace, Chen Simon B, Mullane Patrick, Wu Douglas J, Nesselbush Monica C, Sugio Takeshi, Cheng Jordan C, Jabara Isabel, Hamilton Emily G, Alig Stefan K, Liu Chih-Long, Peterson Dylan J, Prado Kris, Shkolyar Eugene, Thong Alan, Shah Jay B, Gill Harcharan, Kunder Christian A, Chan Emily, Khaki Ali Raza, Skinner Eila C, Alizadeh Ash A, Liao Joseph C, Diehn Maximilian

Abstract excerpt

Only some non-muscle-invasive bladder cancer (NMIBC) patients benefit from intravesical Bacillus Calmette-Guérin (BCG), and predictive biomarkers remain lacking. While urine tumor DNA (utDNA) analysis is promising, mutations in tumor-adjacent normal urothelium, namely the field effect, limit specificity. Here, we show that the prevalence of somatic mutations in the urine increases with age. We introduce an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to BCG Vaccine

Share to Biomarkers, Tumor

Share to DNA, Neoplasm

Share to Liquid Biopsy

Share to Neoplasm, Residual

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41605210
DOI: 10.1016/j.cell.2025.12.054
PMCID: PMC12962748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Field-effect-informed urine liquid biopsy for bladder cancer.PMID 41605210Read ↗

Field cancerization impacts tumor development, T-cell exhaustion and clinical outcomes in bladder cancerSemantic proximity Read ↗

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patientsSemantic proximity Read ↗

Urine Biopsy—Liquid Gold for Molecular Detection and Surveillance of Bladder CancerSemantic proximity Read ↗

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patientsSemantic proximity Read ↗

Biomarkers of Bladder Cancer: Cell-Free DNA, Epigenetic Modifications and Non-Coding RNAsSemantic proximity Read ↗

Mutation Hotspots Found in Bladder Cancer Aid Prediction of Carcinogenic Risk in Normal Urothelium.Semantic proximity Read ↗

Next-generation sequencing of urine specimens: A novel platform for genomic analysis in patients with non-muscle-invasive urothelial carcinoma treated with bacille Calmette-Guérin.Semantic proximity Read ↗

Genomic and Therapeutic Landscape of Non-muscle-invasive Bladder Cancer.Semantic proximity Read ↗

Detection and Surveillance of Bladder Cancer Using Urine Tumor DNASemantic proximity Read ↗

Clinical Utility of Urine DNA for Noninvasive Detection and Minimal Residual Disease Monitoring in Urothelial CarcinomaSemantic proximity Read ↗

Urinary Biomarkers in Bladder Cancer: FDA-Approved Tests and Emerging Tools for Diagnosis and SurveillanceSemantic proximity Read ↗

Tumor heterogeneity and the potential role of liquid biopsy in bladder cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.