Article

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patients

2022-09-23

Abstract excerpt

<title>Abstract</title> <p>Circulating tumor DNA sensitivity remains subpar for minimal residual disease (MRD) detection in bladder cancer patients. To remedy this, we focused on the biofluid most proximal to the disease, urine, and analyzed urine tumor DNA (utDNA) in 74 localized bladder cancer patients. We integrated ultra-low-pass whole genome sequencing (ULP-WGS) with urine Cancer Personalized Profiling by de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0784b506-4aa0-539f-9066-542170e8147e
DOI: 10.21203/rs.3.rs-2019529/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patientsDOI 10.21203/rs.3.rs-2019529/v1Read

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patientsSemantic proximity Read

Clinical Utility of Urine DNA for Noninvasive Detection and Minimal Residual Disease Monitoring in Urothelial CarcinomaSemantic proximity Read

Integrated Plasma and Urinary Cell-free DNA Profiling Enables Noninvasive Molecular Detection from Ta to T4 Bladder CancerSemantic proximity Read

Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.Semantic proximity Read

Deep Sequencing of Urinary RNAs for Bladder Cancer Molecular DiagnosticsSemantic proximity Read

Urine Biopsy—Liquid Gold for Molecular Detection and Surveillance of Bladder CancerSemantic proximity Read

Cell-free urine- and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancerSemantic proximity Read

Biomarkers of Bladder Cancer: Cell-Free DNA, Epigenetic Modifications and Non-Coding RNAsSemantic proximity Read

Detection and Surveillance of Bladder Cancer Using Urine Tumor DNASemantic proximity Read

Genomic complexity of urothelial bladder cancer revealed in urinary cfDNASemantic proximity Read

Emerging Roles of Urine-Based Tumor DNA Analysis in Bladder Cancer ManagementSemantic proximity Read

UCseek: ultrasensitive early detection and recurrence monitoring of urothelial carcinoma by shallow-depth genome-wide bisulfite sequencing of urinary sediment DNASemantic proximity Read