Article
CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2021
Williams Erik A, Montesion Meagan, Alexander Brian M, Ramkissoon Shakti H, Elvin Julia A, Ross Jeffrey S, Williams Kevin Jon, Glomski Krzysztof, Bledsoe Jacob R, Tse Julie Y, Mochel Mark C
Abstract excerpt
Mutations in the tumor suppressor CYLD, known to be causative of cylindromas, were recently described in a subset of high-risk (hr) HPV-positive head and neck squamous cell carcinomas (HNSCC). Pathologic and genetic characterization of these CYLD-mutant carcinomas, however, remains limited. Here, we investigated whether CYLD mutations characterize a histopathologically and genomically distinct subset of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.