Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uncovering metabolite-immune interactions in the pathogenesis of psoriatic arthritis: A 2-sample Mendelian randomization study.

Medicine - 6 Feb 2026

Chen Shuai, Gan Yudong, Jin Yan, Dong Xieping, Wang Feng, Wu Zhongxiong, Liu Zenghui, Zhang Zhongzi

Abstract excerpt

PsA is a chronic inflammatory joint condition associated with psoriasis, and its underlying mechanisms are not fully elucidated. Serum metabolites, as direct reflections of metabolic status, may influence disease progression by regulating immune cell function; however, the causal relationships and specific pathways require further investigation. The present investigation utilized a 2-sample bidirectional MR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Psoriatic
Share to CD14 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41650029
DOI: 10.1097/MD.0000000000047607
PMCID: PMC12885734

Genes

CD14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uncovering metabolite-immune interactions in the pathogenesis of psoriatic arthritis: A 2-sample Mendelian randomization study.PMID 41650029Read ↗

Identifying serum metabolite biomarkers for autoimmune diseases: a two-sample mendelian randomization and meta-analysisSemantic proximity Read ↗

Circulating metabolites mediating the effect of psoriatic arthritis on Crohn disease risk: A mediation Mendelian randomization study.Semantic proximity Read ↗

Causal association between plasma metabolites and diverse autoimmune diseases: a two-sample bidirectional mendelian randomization study.Semantic proximity Read ↗

Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases.Semantic proximity Read ↗

Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis.Semantic proximity Read ↗

The Metabolomic Profile of a Healthy Lifestyle Mediates Psoriasis Risk and Predicts Multiple ComorbiditiesSemantic proximity Read ↗

Identification of causal metabolites related to multiple autoimmune diseases.Semantic proximity Read ↗

Effects of Immune Cells and Plasma Metabolites on Osteoarthritis: A Mediation Mendelian Randomization Study.Semantic proximity Read ↗

The Causal Relationship Between Circulating Metabolites and the Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

The relationship between metabolite mediated immune regulatory imbalance and the occurrence of malignant tumors of bone and articular cartilage: a Mendelian randomization study.Semantic proximity Read ↗

Causality of Genetically Determined Metabolites and Metabolic Pathways on Osteoarthritis: A Bi-Directional Two-Sample Mendelian Randomization StudySemantic proximity Read ↗

Plasma metabolites as mediators in the relationship between inflammation-related proteins and benign prostatic hyperplasia: insights from mendelian randomization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.