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Article

The Gaussian network model as a framework for allosteric analysis: dynamic distance, edge centrality, and entropy sensitivity in KRAS.

Physical biology - 5 Feb 2026

Erman Burak

Abstract excerpt

Allosteric communication in proteins relies on network connectivity patterns that channel conformational signals between distant sites. We introduce a unified mathematical framework based on three complementary measures of network organization derived from a single quantity. The first, the dynamic distanceRij, quantifies the mean-squared relative fluctuation between residue pairs. From this foundation, we derive...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 41592443
DOI: 10.1088/1478-3975/ae3e49

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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