Article
An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.
Haematologica - 1 Jun 2016
Bond Jonathan, Marchand Tony, Touzart Aurore, Cieslak Agata, Trinquand Amélie, Sutton Laurent, Radford-Weiss Isabelle, Lhermitte Ludovic, Spicuglia Salvatore, Dombret Hervé, Macintyre Elizabeth, Ifrah Norbert, Hamel Jean-François, Asnafi Vahid
Abstract excerpt
UNLABELLED: Gene expression studies have consistently identified a HOXA-overexpressing cluster of T-cell acute lymphoblastic leukemias, but it is unclear whether these constitute a homogeneous clinical entity, and the biological consequences of HOXA overexpression have not been systematically examined. We characterized the biology and outcome of 55 HOXA-positive cases among 209 patients with adult T-cell acute...
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