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Evolutionary aspect of spike glycoprotein's conformational dynamics.

Physical chemistry chemical physics : PCCP - 4 Mar 2026

Xu Wentao, Guo Tianyu, Su Haibin

Abstract excerpt

The conformational transition of the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein from the "closed" to the "open" state is an important dynamic event influencing the infectivity of the virus. However, how accumulating mutations reshape these conformational dynamics during viral evolution remains to be clarified. In this study, we observed the motion of the RBD of fully glycosylated S protein...

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Evolution, Molecular
Glycosylation
Molecular Dynamics Simulation
Mutation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Spike Glycoprotein, Coronavirus

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PMID: 41589433
DOI: 10.1039/d5cp04391c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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