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Omicron mutations increase interdomain interactions and reduce epitope exposure in the SARS-CoV-2 spike

20 Jan 2023

Abstract excerpt

Omicron BA.1 is a highly infectious variant of SARS-CoV-2 that carries more than thirty mutations on the spike protein in comparison to the Wuhan wild type (WT). Some of the Omicron mutations, located on the receptor-binding domain (RBD), are exposed to the surrounding solvent and are known to help evade immunity. However, the impact of buried mutations on the RBD conformations and on the mechanics of the spike...

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PMID: 36694788
DOI: 10.1016/j.isci.2023.105981

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