Article
Is there a glucose metabolic signature of spreading TDP-43 pathology in amyotrophic lateral sclerosis?
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... - 1 Mar 2020
van Weehaeghe Donatienne, Ceccarini Jenny, Willekens Stefanie M, de Vocht Joke, van Damme Philip, van Laere Koen
Abstract excerpt
BACKGROUND: Recently, four neuropathological stages of amyotrophic lateral sclerosis (ALS) with spreading of transactive response DNA-binding protein-43 pathology were described. Although 18F-FDG PET has been useful in diagnosis and prognosis of ALS patients, in-vivo disease staging using glucose metabolic patterns across the different ALS stages has not been attempted so far. In this study, we investigated...
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