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Article

Whole-body 18F-FDG PET/CT identifies subclinical metabolic phenotypes in normoglycemic adults.

European journal of nuclear medicine and molecular imaging - 1 Feb 2026

Tao Xuetong, Guan Zilong, Qu Jiaxiang, Sun Qian, Xiao Yong, Li Zhan, Ma Ning, Lin Xiaohua, Wen Guanghua, Zheng Hairong, Liang Dong, Hu Zhanli, Dong Mengjie, Zhang Na

Abstract excerpt

PURPOSE: Early disruptions in systemic glucose regulation may occur even before overt glycemic abnormalities manifest. This study investigated whether patterns of inter-regional glucose uptake coordination, derived from whole-body ¹⁸F-FDG PET/CT, could reveal latent subclinical metabolic phenotypes among normoglycemic adults. METHODS: We analyzed 536 clinically normoglycemic adults (fasting blood glucose < 6.1...

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PMID: 41249716
DOI: 10.1007/s00259-025-07635-y

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