Article
Association of Reduced Brain Metabolism With Motor Function and Survival in Amyotrophic Lateral Sclerosis Patients With Neurofilament Heavy (NEFH) Gene Mutation.
European journal of neurology - 1 Jul 2025
Song Xinyu, Wang Xueying, Hu Fan, Liu Pan, Liu Ziqin, Yi Jiping, Xu Renxu, Cao Wenfeng, Zhang Yuanchao, Wang Junling, Grecucci Alessandro, Yi Xiaoping, Chen Bihong T
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that impairs both upper and lower motor neurons. Mutations in the neurofilament heavy (NEFH) gene are associated with a higher risk for ALS. This study aimed to evaluate the brain metabolism in patients with ALS and NEFH gene mutations (NEFH-ALS) and assess its correlation with emotional and cognitive changes. METHODS: This...
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