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Article

Conplastic FVB/N-mt129S6/SvEvTac mice: A new tool for cancer research.

PloS one - 1 Jan 2026

Gruzdev Artiom, Jefferson Wendy N, Hagler Thomas B, Scott Gregory J, Ray Manas K, Muse Ginger W, Sellers Rani S, Williams Carmen J

Abstract excerpt

FVB/N mice, which are commonly used for cancer studies, have accelerated onset of endometrial cancer following developmental estrogenic chemical exposure. These mice also have a polymorphism in the mitochondrial gene, mt-Atp8, leading to increased production of reactive oxygen species. We hypothesized that this polymorphism contributes to the enhanced endometrial cancer phenotype in FVB/N mice. To test this idea,...

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Identifiers

PMID: 41575966
DOI: 10.1371/journal.pone.0341557
PMCID: PMC12829775

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