Article
Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer.
Neoplasia (New York, N.Y.) - 1 Apr 2015
Felts Sara J, Van Keulen Virginia P, Hansen Michael J, Bell Michael P, Allen Kathleen, Belachew Alem A, Vile Richard G, Cunningham Julie M, Hoskin Tanya L, Pankratz V Shane, Pease Larry R
Abstract excerpt
Breast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and sporadic loss or gain of other chromosomes. We employed the Illumina GoldenGate genotyping platform to quantitate loss of heterozygosity (LOH) across the genome of primary tumors, revealing strong biases favoring chromosome 4 alleles from the FVB parent. While allelic bias was not observed on other chromosomes, many tumors...
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