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Article

Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program.

Cancer science - 1 Jul 2013

Toki Hideaki, Inoue Maki, Motegi Hiromi, Minowa Osamu, Kanda Hiroaki, Yamamoto Noriko, Ikeda Ami, Karashima Yuko, Matsui Junko, Kaneda Hideki, Miura Ikuo, Suzuki Tomohiro, Wakana Shigeharu, Masuya Hiroshi, Gondo Yoichi, Shiroishi Toshihiko, Akiyama Tetsu, Yao Ryoji, Noda Tetsuo

Abstract excerpt

Mutant mouse models are indispensable tools for clarifying the functions of genes and elucidating the underlying pathogenic mechanisms of human diseases. We carried out large-scale mutagenesis using the chemical mutagen N-ethyl-N-nitrosourea. One specific aim of our mutagenesis project was to generate novel cancer models. We screened 7012 animals for dominant traits using a necropsy test and thereby established...

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Identifiers

PMID: 23551873
DOI: 10.1111/cas.12161
PMCID: PMC7657124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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