Article
Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase.
Toxicology and applied pharmacology - 1 Apr 2011
Miller Lutfiya, Wells Peter G
Abstract excerpt
The mechanisms underlying the teratogenicity of methanol (MeOH) in rodents, unlike its acute toxicity in humans, are unclear, but may involve reactive oxygen species (ROS). Embryonic catalase, although expressed at about 5% of maternal activity, may protect the embryo by detoxifying ROS. This hypothesis was investigated in whole embryo culture to remove confounding maternal factors, including metabolism of MeOH...
Topics
- Acatalasia
- Animals
- Catalase
- Embryo, Mammalian
- Female
- Fetal Diseases
- Gene Expression Regulation, Enzymologic
- Humans
- Methanol
- Mice
- Mice, Inbred C3H