Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

CHIT: an allele-specific method for testing the association between molecular quantitative traits and phenotype-genotype interaction.

Bioinformatics (Oxford, England) - 11 Dec 2021

Yan Qi, Forno Erick, Celedón Juan C, Chen Wei, Weeks Daniel E

Abstract excerpt

MOTIVATION: Allele-specific differences in molecular traits can be obtained from next-generation sequencing data and could potentially improve testing power, but such information is usually overlooked in association studies. Furthermore, the variation of molecular quantitative traits (e.g. gene expression) could result from the interaction effect of genotypes and phenotypes, but it is challenging to identify such...

Topics

Join the communities discussing this publication.

Algorithms
Alleles
Chromosome Mapping
Genotype
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Programming Languages

Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 34323937
DOI: 10.1093/bioinformatics/btab554
PMCID: PMC8711119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHIT: an allele-specific method for testing the association between molecular quantitative traits and phenotype-genotype interaction.PMID 34323937Read ↗

LRphase: an efficient method for assigning haplotype identity to long readsSemantic proximity Read ↗

JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression.Semantic proximity Read ↗

Transethnic Genetic-Correlation Estimates from Summary Statistics.Semantic proximity Read ↗

Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes.Semantic proximity Read ↗

Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypesSemantic proximity Read ↗

JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expressionSemantic proximity Read ↗

A Novel Test for Detecting SNP-SNP Interactions in Case-Only Trio Studies.Semantic proximity Read ↗

Identifying Genetic Regulatory Variants that Affect Transcription Factor ActivitySemantic proximity Read ↗

Allele-specific expression reveals interactions between genetic variation and environmentSemantic proximity Read ↗

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levelsSemantic proximity Read ↗

Predicting genotype-specific gene regulatory networksSemantic proximity Read ↗

MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.