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JEM: A joint test to estimate the effect of multiple genetic variants on DNA methylation.

Genetic epidemiology - 1 Apr 2021

Sarnowski Chloé, Huan Tianxiao, Jain Deepti, Liu Chunyu, Yao Chen, Joehanes Roby, Levy Daniel, Dupuis Josée

Abstract excerpt

Multiple methods have been proposed to aggregate genetic variants in a gene or a region and jointly test their association with a trait of interest. However, these joint tests do not provide estimates of the individual effect of each variant. Moreover, few methods have evaluated the joint association of multiple variants with DNA methylation. We propose a method based on linear mixed models to estimate the joint...

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Identifiers

PMID: 33038041
DOI: 10.1002/gepi.22369
PMCID: PMC8005415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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