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Article

Leveraging Methylome-Environment Interaction to Detect Genetic Determinants of Disease.

Human heredity - 1 Jan 2016

Slade Emily, Kraft Peter

Abstract excerpt

OBJECTIVE: The association between DNA methylation and a trait of interest may depend on an environmental exposure, and incorrectly accounting for this dependence can lead to a reduction in power of the standard tests used in epigenome-wide association studies. We present the M-ME test to jointly test for the main effect of DNA methylation and methylation-environment interaction. METHODS: Through simulation, we...

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Identifiers

PMID: 27490128
DOI: 10.1159/000447357
PMCID: PMC5621601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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