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Article

Association between systemic redox balance and osteoporosis: prospective evidence, polygenic modification, and proteomic and inflammatory mediation in the UK Biobank.

Bone - 1 Apr 2026

Zhu Yuanpeng, Liu Di, Yin Xiangjie, Zhang Terry Jianguo, Wu Nan

Abstract excerpt

PURPOSE: Redox signaling governs bone remodeling, but whether systemic redox balance is associated with incident osteoporosis, genetic susceptibility, and proteomic/inflammatory pathways at population scale remains unclear. METHODS: We analyzed UK Biobank participants free of osteoporosis at baseline. Serum redox balance score (SRBS) combined albumin, total bilirubin, and γ-glutamyl transferase. Cox proportional...

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Identifiers

PMID: 41570964
DOI: 10.1016/j.bone.2026.117802

Genes

CBLN4
CD27
EGFR
IGDCC4
TNFRSF10A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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