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Article

Unveiling Epigenetic Molecular Mechanisms in Bone Fracture Risk: Insights From 731 Immune Cells, 1400 Metabolites, and Critical Genetic Pathways.

Mediators of inflammation - 1 Jan 2026

Wan Xiaomin, Lu Wuchao, Xue Jizhao, Huang Jiaxin, Qian Weihong, Hu Zhuoyi, You Wulin, Zhang Yafeng

Abstract excerpt

BACKGROUND: The aging population and advancements in medical science have heightened the focus on fractures, which affect over 150 million individuals annually, with substantial health and economic consequences. OBJECTIVE: This study investigated the potential causal relationships between 731 immune cells, 1400 metabolites, and nine fracture types using Mendelian randomization (MR). METHODS: A combination of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41960642
DOI: 10.1155/mi/3846184
PMCID: PMC13067064

Genes

CD28
ITGB1
STAT3
CD8A
ITPR1
PRKACA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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