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Article

Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization.

Frontiers in public health - 1 Jan 2022

Yu Xing-Hao, Cao Rong-Rong, Yang Yi-Qun, Zhang Lei, Lei Shu-Feng, Deng Fei-Yan

Abstract excerpt

Purpose: Osteoporosis is associated with metabolic alterations, but the causal roles of serum metabolites on osteoporosis have not been identified. Methods: Based on the large individual-level datasets from UK Biobank as well as GWAS summary datasets, we first constructed genetic risk scores (GRSs) for 308 of 486 human serum metabolites and evaluated the effect of each GRS on 2 major osteoporosis phenotypes,...

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Source

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Identifiers

PMID: 36091497
DOI: 10.3389/fpubh.2022.905178
PMCID: PMC9452842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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