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Serum creatinine, genetic susceptibility, and the risk of osteoporosis and fracture: a prospective cohort study from the UK Biobank.

Frontiers in endocrinology - 1 Jan 2025

He Weijie, Zhou Yu, Ding Jiaxuan, Jiang Jiale, Zhang Hang, Hu Chonghui, Liu Qiongyan, Gu Honglin, Chen Huimou

Abstract excerpt

Background: Osteoporosis imposes a substantial fracture burden, yet scalable and dynamic biomarkers for risk stratification remain limited. Serum creatinine-routinely assayed and capturing intertwined muscle and renal signals-has been little studied for incident osteoporosis or fractures. Methods: In the UK Biobank, covariate-adjusted Cox models and restricted cubic splines assessed associations of baseline...

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Identifiers

PMID: 41641030
DOI: 10.3389/fendo.2025.1727636
PMCID: PMC12864067

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