Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Impact of Pathogenic Germline Variants in Pancreatic Cancer: Results From a Multicenter, Prospective, Universal Genetic Testing Study.

Clinical and translational gastroenterology - 8 Oct 2021

Uson Pedro L S, Samadder N Jewel, Riegert-Johnson Douglas, Boardman Lisa, Borad Mitesh J, Ahn Daniel, Sonbol Mohamad B, Faigel Douglas O, Fukami Norio, Pannala Rahul, Kunze Katie, Golafshar Michael, Klint Margaret, Esplin Edward D, Nussbaum Robert L, Stewart A Keith, Bekaii-Saab Tanios

Abstract excerpt

INTRODUCTION: To report the prevalence and outcomes of unselected pancreatic cancer (PC) patients with pathogenic/likely pathogenic germline variants (PGVs) detected using a universal testing approach. METHODS: We undertook a prospective, multisite study of germline sequencing using a >80 gene next-generation sequencing platform among 250 patients with PC (not selected for age or family history of cancer) between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasm Staging

Share to Pancreatic and Hepatic Oncology Research

Share to Pancreatic Neoplasms

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 34620795
DOI: 10.14309/ctg.0000000000000414
PMCID: PMC8500569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Impact of Pathogenic Germline Variants in Pancreatic Cancer: Results From a Multicenter, Prospective, Universal Genetic Testing Study.PMID 34620795Read ↗

Prevalence of Germline Sequence Variations Among Patients With Pancreatic Cancer in China.Semantic proximity Read ↗

Detection of germline variants using expanded multigene panels in patients with localized pancreatic cancer.Semantic proximity Read ↗

Germline Pathogenic Variants in Patients with Pancreatic Ductal Adenocarcinoma and Extra-Pancreatic Malignancies: A Nationwide Database AnalysisSemantic proximity Read ↗

Universal Panel Testing of Pancreatic Cancer Cases for Cancer PredispositionSemantic proximity Read ↗

Germline Cancer Testing in Unselected Patients with Gastric and Esophageal Cancers: A Multi-center Prospective Study.Semantic proximity Read ↗

Prevalence and impact of germline mutations in pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Prevalence and spectrum of germline pathogenic variants in cancer susceptibility genes among mexican patients with exocrine pancreatic cancer.Semantic proximity Read ↗

Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes.Semantic proximity Read ↗

Germline Variants and Risk for Pancreatic Cancer: A Systematic Review and Emerging Concepts.Semantic proximity Read ↗

A systematic review of the prevalence of germline pathogenic variants in patients with pancreatic cancer.Semantic proximity Read ↗

Prospective study of germline genetic testing in incident cases of pancreatic adenocarcinoma.Semantic proximity Read ↗

Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.