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Meiotic Cohesin and Variants Associated With Human Reproductive Aging and Disease

2 Aug 2021

Abstract excerpt

Successful human reproduction relies on the well-orchestrated development of competent gametes through the process of meiosis. The loading of cohesin, a multi-protein complex, is a key event in the initiation of mammalian meiosis. Establishment of sister chromatid cohesion via cohesin rings is essential for ensuring homologous recombination-mediated DNA repair and future proper chromosome segregation. Cohesin...

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PMID: 34409039
DOI: 10.3389/fcell.2021.710033

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