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Article

Maternal genetic variants associated with aneuploid conception: a narrative review.

Human reproduction update - 1 Sept 2026

Ha Siyao, Liu Wenyi, Yuan Ping, Yuan Shangya, Cao Chunwei, Meng Anming, Chen Hui

Abstract excerpt

BACKGROUND: Human aneuploid conception, a leading cause of infertility, pregnancy loss, and congenital disorders (e.g. Down's syndrome), arises from errors in chromosome segregation during oocyte meiosis or embryonic mitosis. While advanced maternal age is a well-established risk factor, significant inter-individual variation exists among younger women, suggesting a substantial role for maternal genetic...

Read the complete abstract on PubMed

Topics

Humans
Aneuploidy
Female
Pregnancy
Genetic Variation
Fertilization

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42124334
DOI: 10.1093/humupd/dmag012

Genes

BUB1B
CCDC66
CEP120
ELL3
HFM1
KIF18A
MCM9
MEI1
NLRP2
NLRP7
PLK4
TLE6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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