Elucidating the mutation-induced conformational changes in hexose transporter for co-utilization of glucose and xylose.

Abstract excerpt

Efficient co-utilization of glucose and xylose by Saccharomyces cerevisiae is crucial for economical biofuel production from renewable feedstocks. The F79S mutation in the hexose transporter HXT7 enhances xylose uptake, but the underlying molecular mechanism remains elusive. We employ molecular dynamics simulations to elucidate the conformational changes induced by the F79S mutation and xylose binding. The...

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• Glucose
• Molecular Dynamics Simulation
• Monosaccharide Transport Proteins
• Mutation
• Protein Conformation