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Article

Engineering yeast hexokinase 2 for improved tolerance toward xylose-induced inactivation.

PloS one - 1 Jan 2013

Bergdahl Basti, Sandström Anders G, Borgström Celina, Boonyawan Tarinee, van Niel Ed W J, Gorwa-Grauslund Marie F

Abstract excerpt

Hexokinase 2 (Hxk2p) from Saccharomyces cerevisiae is a bi-functional enzyme being both a catalyst and an important regulator in the glucose repression signal. In the presence of xylose Hxk2p is irreversibly inactivated through an autophosphorylation mechanism, affecting all functions. Consequently, the regulation of genes involved in sugar transport and fermentative metabolism is impaired. The aim of the study...

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PMID: 24040384
DOI: 10.1371/journal.pone.0075055
PMCID: PMC3765440

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