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Article

Relief of Xylose Binding to Cellobiose Phosphorylase by a Single Distal Mutation.

ACS synthetic biology - 17 Feb 2017

Chomvong Kulika, Lin Eric, Blaisse Michael, Gillespie Abigail E, Cate Jamie H D

Abstract excerpt

Cellobiose phosphorylase (CBP) cleaves cellobiose-abundant in plant biomass-to glucose and glucose 1-phosphate. However, the pentose sugar xylose, also abundant in plant biomass, acts as a mixed-inhibitor and a substrate for the reverse reaction, limiting the industrial potential of CBP. Preventing xylose, which lacks only a single hydroxymethyl group relative to glucose, from binding to the CBP active site poses...

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PMID: 27676450
DOI: 10.1021/acssynbio.6b00211

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